I had the same problem when I upgraded to AS 4.2 from 4.1.
I had no issues with my home computer, but I had the problem with my work computer.
I found this solution and it worked like a charm.
# re: Activesync 4.2 now available for download
Friday, July 28, 2006 5:13 PM by Alan Tetley [MSFT]
ActiveSync version 4.2 made a change to how it interacts with the Windows networking stack to use Layered Service Providers (LSPs) on outgoing Desktop-Pass-Through connections. This allows for improved compatibility & policy compliance in environments where connections to the internet must be passed through these LSPs (ISA Proxy is one such example).
Unfortunately, it appears this change has caused some issues for a small segment of users who have LSPs that interfere with ActiveSync communication.
There is a registry key which can be created to essentially remove this change & revert to ActiveSync 4.1 behaviour. This key is:
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows CE Services]
"AllowLSP"=dword:0
This posting is provided "AS IS" with no warranties, and confers no rights.
Source: http://blogs.msdn.com/jasonlan/archive/2006/07/07/659348.aspx
>I have an O2 XDA exec WM5 and AS 4.2.0(Build4876) and cannot get access to
> the internet while connected with AS via USB
> Get the error "The page you are looking for cannot be found due to unkown
> error 0x80072f78."
>
> Any ideas?